WebWe expressed the diphtheria toxin (DT) receptor in transgenic mice using a hepatocyte-specific promoter and found that injection of DT caused fulminant hepatitis. Three … WebSep 1, 1990 · Diphtheria toxin (DTX)-sensitive mouse cells were isolated from a toxin-resistant thymidine kinase (TK)-negative L-M(TK-) mouse cell population that was …
Diphtheria toxin - Wikipedia
Diphtheria toxin is an exotoxin secreted by mainly by Corynebacterium diphtheriae but also by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. the pathogenic bacterium that causes diphtheria. The toxin gene is encoded by a prophage called corynephage β. The toxin … See more Diphtheria toxin is a single polypeptide chain of 535 amino acids consisting of two subunits linked by disulfide bridges, known as an A-B toxin. Binding to the cell surface of the B subunit (the less stable of the two subunits) allows the … See more Diphtheria toxin is extraordinarily potent. The lethal dose for humans is about 0.1 μg of toxin per kg of body weight. Death occurs through necrosis of the heart and liver. Diphtheria toxin has also been associated with the development of myocarditis. … See more The drug denileukin diftitox uses diphtheria toxin as an antineoplastic agent. Resimmune is an immunotoxin that is in clinical trials in See more Similar to other A-B toxins, diphtheria toxin is adept at transporting exogenous proteins across mammalian cell membranes, which are usually impermeable to … See more 1. Processing 2. The toxin binds to heparin-binding epidermal growth factor precursor (HB-EGF). 3. The complex undergoes endocytosis by the host cell. 4. Acidification inside the endosome induces translocation of the A subunit into the cytosol. See more Diphtheria toxin was discovered in 1888 by Émile Roux and Alexandre Yersin. In 1890, Emil Adolf von Behring developed an anti-toxin based on the blood of horses immunized with attenuated bacteria. In 1951, Freeman found that the toxin gene was not encoded … See more 1. ^ A prophage is a virus that has inserted itself into the genome of the host bacterium. See more WebJul 28, 2024 · Diphtheria toxin (DTx) is a well-known bacterial toxin inducing various cytotoxic effects. Mainly, catalytic fragment inhibits protein synthesis, induces cytotoxicity, and depolymerizes actin filaments. In this study, we aimed to demonstrate the extent of myofibrillar damage under DTx treatment to porcine cardiac tissue samples. Methods … space sniff下载
2650491 - Gene ResultDIP_RS12515 toxin [] - National Center for ...
WebAug 28, 2024 · Corynebacterium diphtheria is anaerobic, Gram-positive, non-motile, non-spore-forming, non-capsulated, toxin-producing, pleomorphic coccobacillus, which is usually club-shaped. Based on biochemical properties and colony morphology, it has four biotypes, namely, gravis, mitis, intermedius, and belfanti. WebExplore the latest full-text research PDFs, articles, conference papers, preprints and more on CELL LYSIS. Find methods information, sources, references or conduct a literature review on CELL LYSIS WebIn recent years considerable advances have been made in the understanding of the molecular basis of iron-mediated regulation of diphtheria toxin expression. The tox gene has been shown to be regulated by the heavy metal ion-activated regulatory element DtxR. In the presence of divalent heavy metal ions, DtxR becomes activated and binds to a 9 ... teams school and work login