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Diphtheria toxin dtx

WebWe expressed the diphtheria toxin (DT) receptor in transgenic mice using a hepatocyte-specific promoter and found that injection of DT caused fulminant hepatitis. Three … WebSep 1, 1990 · Diphtheria toxin (DTX)-sensitive mouse cells were isolated from a toxin-resistant thymidine kinase (TK)-negative L-M(TK-) mouse cell population that was …

Diphtheria toxin - Wikipedia

Diphtheria toxin is an exotoxin secreted by mainly by Corynebacterium diphtheriae but also by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. the pathogenic bacterium that causes diphtheria. The toxin gene is encoded by a prophage called corynephage β. The toxin … See more Diphtheria toxin is a single polypeptide chain of 535 amino acids consisting of two subunits linked by disulfide bridges, known as an A-B toxin. Binding to the cell surface of the B subunit (the less stable of the two subunits) allows the … See more Diphtheria toxin is extraordinarily potent. The lethal dose for humans is about 0.1 μg of toxin per kg of body weight. Death occurs through necrosis of the heart and liver. Diphtheria toxin has also been associated with the development of myocarditis. … See more The drug denileukin diftitox uses diphtheria toxin as an antineoplastic agent. Resimmune is an immunotoxin that is in clinical trials in See more Similar to other A-B toxins, diphtheria toxin is adept at transporting exogenous proteins across mammalian cell membranes, which are usually impermeable to … See more 1. Processing 2. The toxin binds to heparin-binding epidermal growth factor precursor (HB-EGF). 3. The complex undergoes endocytosis by the host cell. 4. Acidification inside the endosome induces translocation of the A subunit into the cytosol. See more Diphtheria toxin was discovered in 1888 by Émile Roux and Alexandre Yersin. In 1890, Emil Adolf von Behring developed an anti-toxin based on the blood of horses immunized with attenuated bacteria. In 1951, Freeman found that the toxin gene was not encoded … See more 1. ^ A prophage is a virus that has inserted itself into the genome of the host bacterium. See more WebJul 28, 2024 · Diphtheria toxin (DTx) is a well-known bacterial toxin inducing various cytotoxic effects. Mainly, catalytic fragment inhibits protein synthesis, induces cytotoxicity, and depolymerizes actin filaments. In this study, we aimed to demonstrate the extent of myofibrillar damage under DTx treatment to porcine cardiac tissue samples. Methods … space sniff下载 https://ronnieeverett.com

2650491 - Gene ResultDIP_RS12515 toxin [] - National Center for ...

WebAug 28, 2024 · Corynebacterium diphtheria is anaerobic, Gram-positive, non-motile, non-spore-forming, non-capsulated, toxin-producing, pleomorphic coccobacillus, which is usually club-shaped. Based on biochemical properties and colony morphology, it has four biotypes, namely, gravis, mitis, intermedius, and belfanti. WebExplore the latest full-text research PDFs, articles, conference papers, preprints and more on CELL LYSIS. Find methods information, sources, references or conduct a literature review on CELL LYSIS WebIn recent years considerable advances have been made in the understanding of the molecular basis of iron-mediated regulation of diphtheria toxin expression. The tox gene has been shown to be regulated by the heavy metal ion-activated regulatory element DtxR. In the presence of divalent heavy metal ions, DtxR becomes activated and binds to a 9 ... teams school and work login

Myofibrillar degeneration with diphtheria toxin Semantic Scholar

Category:Impairment of podocyte function by diphtheria toxin--a new …

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Diphtheria toxin dtx

Impairment of podocyte function by diphtheria toxin--a new …

WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Support Center Find answers to questions about products, access, use, setup, and administration.; Contact Us Have a question, idea, or some feedback? We want to hear from you. WebIron dependent repressor. In molecular biology, the iron dependent repressors are a family of bacterial and archaeal transcriptional repressors . At their N-terminus they contain a dtxR-type HTH domain. This is a DNA -binding, winged helix-turn-helix (wHTH) domain of about 65 amino acids present in metalloregulators of the dtxR/mntR family. The ...

Diphtheria toxin dtx

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WebDiphtheria toxin (DTx) provokes extensive internucleosomal degradation of DNA before cell lysis. The possibility that DNA cleavage stems from direct chromosomal attack by … WebSep 24, 2012 · Diphtheria toxin (DTx) receptor (DTR)-mediated conditional cell ablation in transgenic mice is a powerful tool to analyze cell function in vivo. Transgenic mice with …

WebADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. Improper ADP-ribosylation has been implicated in some forms of cancer. It is also the basis for the … WebDiphtheria toxin is a bacterial toxin produced from Corynebacterium diphtheriae. It contains three domains that have intracellular actions. The domains are involved in the …

WebDiphtheria toxin (DTx) is a well-characterized toxic protein (1, 2). It has two functional domains, A and B, which can be resolved by limited proteolytic digestion and reduction of an interchain disulfide bond. Intoxication of cells by DTx in-volves endocytosis of receptor-bound toxin. Once the toxin WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Support Center Find answers to questions about products, …

WebDiphtheria toxin (DTx) is a secreted molecule of 58.35 kDa produced by Corynebacterium diphtheriae and composed of two functional subunits: subunit A encompasses the …

WebMice heterozygous for diptheria toxin receptor (DTR) fused with green fluorescent protein (GFP) were exposed to OVA and RV in the presence or absence of diphtheria toxin (DTX). ( A ) Flow analysis to detect the presence of GFP+, CD11b+, and DTR+ cells from various treatment groups in combination with the detection of intracellular IL-13. teams school work log inWebABSTRACT Diphtheria toxin (DTx) is an extremely po-tent inhibitor of protein synthesis. It is secreted as a linear polypeptide, which is cleaved to produce disulfide-linked A and B … spaces of metrics and curvature functionalsWebDiphtheria toxin (DTx) receptor (DTR)-mediated conditional cell ablation in transgenic mice is a powerful tool to analyze cell function in vivo. Transgenic mice with cell-specific expression of the human DTR have been developed that allow conditional depletion of these cells in vivo through administration of the toxin. We have performed a ... teams schulung youtubeWebDiphtheria toxin (DTx) is a well-known bacterial toxin inducing various cytotoxic effects. Mainly, catalytic fragment inhibits protein synthesis, induces cytotoxicity, and depolymerizes actin ... spaces of the handWebDec 8, 1998 · The diphtheria toxin repressor DtxR from Corynebacterium diphtheriae has been shown to be an iron-activated regulatory element that controls the expression of a series of iron-sensitive genes, including the diphtheria toxin structural gene, genes involved in siderophore production, and heme oxygenase (1–4).Partial x-ray structures of … teamsscoopWebWe have approached this problem by comparing the biological properties of TNF with diphtheria toxin (DTx), a well-characterized cytotoxin. Initial studies with human U937 cells revealed that a transient exposure to low pH enhances the cytotoxic activity of TNF. Detailed studies on the interaction of TNF with pure lipid vesicles revealed that ... teams scolaireWebOct 1, 1992 · The results indicated that even though the antisera were raised to peptides containing 14 amino acids (aa) they were directed predominantly against a narrow region within the peptide, consisting of only 5-6 aa residues. Antibodies highly selective for two functionally distinct regions of diphtheria toxin (DTx) were prepared using synthetic … teams scope directory search